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TRANSFORMING GROWTH FACTOR BETA1
Descriptors Found:
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DeCS
Descriptor
English
:
Transforming Growth Factor beta1
Descriptor
Spanish
:
Factor de Crecimiento Transformador beta1
Descriptor
Portuguese
:
Fator de Crescimento Transformador beta1
Synonyms
English
:
TGF-beta1
Tree Number:
D12.644.276.374.687.100
D12.644.276.954.800.720.100
D12.644.276.963.720.100
D12.776.467.374.687.100
D12.776.467.942.800.720.100
D12.776.467.960.720.100
D23.529.374.687.100
D23.529.942.800.720.100
D23.529.960.720.100
Definition
English
:
A subtype of
transforming growth factor beta
that is synthesized by a wide variety of
cells
. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The
association
of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of
CAMURATI-ENGELMANN SYNDROME.
Entry Combination - descr/qualif
English
:
Transforming Growth Factor beta1
/
deficiency
use
Camurati-Engelmann Syndrome
History Note
English
:
2007(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52285
Unique Identifier:
D053773
Occurrence in VHL
:
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